BMB 178 SYLLABUS Fall 2017
http://saf.bio.caltech.edu/bmb178/
Wed/Fri 10:30 A.M. - 12 NOON
101 Schlinger

Instructor:
  Shu-ou Shan 
    109 Braun, x3879, sshan@caltech.edu
Teaching Assistants:  121 Braun, x4071
    Hao-Hsuan Hsieh hhsieh@caltech.edu 
    Chien-I Yang cyang3@caltech.edu 
    Jae Ho Lee leej87@caltech.edu 
    Office hours in 121 Braun: 7-9 pm 10/11(JHL); 11/1(CY), 11/27(HH)
    Additional office hours are available by appointment.
Textbook: 
  A. Fersht, "Structure and Mechanism in Protein Science", 3rd edition (2000) or later.
  A copy is on reserve in the library.  An electronic copy of this book is freely available
  on http://fersht.com/Structure.html.
Lectures:
Date    Topic                                                           HW Set
9/27  	Introduction; review of basic thermodynamics; 
           transition state theory					 
9/29  	Transition state theory continued and ramifications;            #1 posted
           pymol tutorial

10/4    Covalent catalysis; General acid/base catalysis                                     
10/6    Metal ions; Electrostatics and hydrogen bonds

10/11   Entropy, intrinsic binding energy and the Circe effect
10/13   Specificity and editing; promiscuity and enzyme evolution 	#1 due			

10/18   Cooperativity and allostery   			                #2 posted		
10/20   Kinetics 101: rate laws, rate limiting steps

10/25   Steady state kinetics (I)
10/27   Steady state kinetics (II)  Presteady-state kinetics
          Schedule literature discussions

11/01   Literature discussion (I)                                            
11/03   Literature discussion (II)                                      #2 due 

11/08   Pre-steady state kinetics (II)                                  #3 posted   
11/10   Pre-steady state kinetics (III); Overview of analytical tools              
	
11/15   Kinetics simulations	                                
11/17   Single molecule kinetics (I)
	
11/22   Single molecule kinetics (II)						
11/24   No class (Thanksgiving)      

11/29   Enzyme design and evolution                                     #3 due
12/01   Literature discussion (III) TQFR

12/4    Finals Posted
12/8	Finals due by 5PM.  In front of Shu-ou's office (109 Braun). 

Last modified 21-SEP-2017