BMB/Ch 178 SYLLABUS Fall 2018
http://saf.bio.caltech.edu/bmb178/
Wed/Fri 10:30 A.M. - 12 NOON
101 Schlinger

Instructor:
  Shu-ou Shan 
    109 Braun, x3879, sshan@caltech.edu
Teaching Assistants:  121 Braun, x4071
    Hao-Hsuan Hsieh hhsieh@caltech.edu 
    Chien-I Yang cyang3@caltech.edu 
    Inha Cho icho@caltech.edu 
    Office hours in 218 SFL: 7-9 pm 10/25(IC); 11/12(CY), 12/3(HH)
    Additional office hours are available by appointment.
Textbook: 
  A. Fersht, "Structure and Mechanism in Protein Science", 3rd edition (2000) or later.
  A copy is on reserve in the library.  An electronic copy of this book is freely available
  on http://fersht.com/Structure.html.
Lectures:
Date    Topic                                                           HW Set
10/3  	Introduction; review of basic thermodynamics; 
           transition state theory					 
10/5  	How to map transition state; Covalent catalysis

10/10   Covalent catalysis (cont.); General acid/base catalysis         #1 posted                                
10/12   Metal ions; Electrostatics and hydrogen bonds

10/17   Entropy, intrinsic binding energy and the Circe effect
10/19   Specificity and editing; Promiscuity and enzyme evolution			

10/24   Pymol Tutorial (TAs); Berkeley Madonna Tutorial		
10/26   Electron Transfer reactions (Harry Gray and Jay Winkler)        #1 due

10/31   Cooperativity and allostery                                     #2 posted
11/2    Kinetics 101: rate laws, rate limiting steps
          Schedule literature discussions

11/07   Steady state kinetics (I)                                            
11/09   Steady state kinetics (II)  Presteady-state kinetics (I)                                

11/14   Pre-steady state kinetics (II)                                  #2 due 
11/16   Pre-steady state kinetics (III); Overview of analytical tools   #3 posted              
	
11/21   Overview of biophysical tools						
11/23   No class (Thanksgiving)      

11/28   Single molecule kinetics (I)                               
11/30   Single molecule kinetics (II)Literature discussion (III)

12/5    Literature discussion (I)                                       #3 due
12/7	Literature discussion (II)  TQFR

12/11   Finals Posted
12/14	Finals due by 6PM.  In front of Shu-ou's office (109 Braun). 

Last modified 27-SEP-2018