BMB/Ch 178 Lecture Notes Fall 2016

Macromolecular Function: Kinetics, Energetics, and Mechanisms

(Links may point to empty files until the real ones are uploaded.)
Date Subject Notes Recommended Reading
1 9/28 Introduction; review of basic thermodynamics; transition state theory PDF link
2 9/30 Transition state theory continued and ramifications; PyMOL tutorial PDF link
3 10/5 Covalent catalysis; General acid/base catalysis PDF link
4 10/07 Metal ions; Electrostatics and hydrogen bonds PDF link
5 10/12 Entropy, intrinsic binding energy and the Circe effect PDF link
6 10/14 Specificity and editing mechanisms; promiscuity and enzyme evolution PDF link
7 10/19 Cooperativity and allostery PDF link
8 10/21 Kinetics 101: rate laws, rate limiting steps PDF link
9 10/26 Steady state kinetics (I) PDF link
10 10/28 Steady state kinetics (II), Presteady-state kinetics (I) PDF PDF link
11 11/2 Pre-steady state kinetics (II) PDF PDF link
12 11/4 Pre-steady state kinetics (III) PDF link
13 11/09 Literature Discussion (I) - -
14 11/11 Literature discussion (II) - -
15 11/16 Kinetics simulations PDF link
16 11/18 Single molecule kinetics (II) PDF link
17 11/23 Single molecule kinetics (III) PDF link
- 11/25 No class (Thanksgiving) - -
18 11/30 Enzyme design and evolution PDF link
19 12/2 Literature discussion (II) - -
Last modified 30-NOV-2016