Course content: This course will focus on critical literature reading on specific topics that can incorporate broadly the lessons, concepts and techniques learned in BMB170, 173 and 178. The goal is to reinforce these concepts and techniques and synthesize them through real case studies of macromolecular assemblies in biology. The emphasis will be on the key experiments that lead to our current understanding of the biological system under investigation. The course consummates in the development of an original research proposal by the students.
Course prerequisites: BMB/Bi/Ch 170, 173 and 174 are intended as a year-long 'core' sequence. It is therefore expected that all students participating in this class have finished BMB/Bi/Ch 170 and 173. Students who wish to enroll in this class, but who have not attended the first two quarters of this series, will need permission from the course instructor.
Reading material:Most of the classes are in a flipped classroom format based on literature discussion. Students are required to read the designated papers and be prepared to answer questions in class.
Class web page: http://saf.bio.caltech.edu/bi174/
Midterm: The midterm is a 1-page essay that requires each student to choose a topic of interest relevant to the interaction, structure and/or function of macromolecular assemblies or pathways. The topic must be out-of-field, i.e., it is a subject that you have not, are not, and will not be working on. Explain an outstanding question in the field, analyze the current models and the evidences / arguments supporting each. This serves as the basis to generate your final proposal. Midterm is due May 3, at 6 pm. Send the midterm essay to firstname.lastname@example.org. Students will form discussion groups to provide constructive feedback on each otherís proposal.
Final: The final will be an "out-of-field" research proposal based on the topic you choose in the mid-term assay. Describe a series of experimental designs that address an outstanding question in the field and distinguishes / resolves disparate models. The proposal is due June 5, at 6 pm. Send the final proposal to email@example.com.Students will also form study sessions to review, discuss, and score the proposals on June 9th. Note that this is an important part of the learning process, and the quality of your peer review on the proposal also counts into the grade.
Grading:The course is offered for a letter grade only. Literature discussions will be worth 50%, the midterm 10%, the final 25%, and the quality of peer review 15%.TA Contact Information
|Sho Harvey||Broad 121 Braunfirstname.lastname@example.org||x??? cell|
|Chengcheng Fan||Broad email@example.com||x8392 cell|
|Matthew Zimmer||220 SFLfirstname.lastname@example.org||x5841 cell|
|4/9(M), 4/11(W), 4/23(M), 5/2(W), 5/9(W), 5/14(M), 5/16(W)||6:00-8:00 PM||Sho Harvey||121 Braun|
|4/16(M), 4/18(W), 4/25(W), 4/30(M), 5/21(M), 5/23(W), 5/28(M)||5:00-6:00 PM||Chengcheng Fan||300 Broad|
|5/1(T), 5/15(T), 5/25(F), 6/1(F)||5:00-6:00 PM||Matthew Zimmer||220 SFL|